I recently ran into a case where selecting the next value from a sequence was causing contention issues in Oracle RAC. See this screen shot from Lighty (click on the image to see a larger picture)
The wait events will look the same if viewed in Enterprise Manager’s performance screens, which does require one to license the optional Diagnostics Pack.
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We can see high waits on the row cache lock wait event as well as multiple global cache wait events (all start with “gc”).
The problem was the sequence was created with CACHE set to zero. Sequences in Oracle RAC with a cache setting too low will see wait events like this. The solution is simple, increase the CACHE size.